PEG, polyethylene glycol, traditionally refers to the one with low molecular weight (MW<20 kDa); while its higher MW adduct is usually called as polyethylene oxide (PEO). PEG has several chemical attributes that make it especially useful in various biological, pharmaceutical, and chemical settings. For example:
Non-toxic / non-immunogenic – can be added to media and attached to surfaces and conjugated to molecules without interfering with cellular functions or target immunogenicities
Hydrophilic – attachment to proteins and other biomolecules decreases aggregation and increases solubility
Highly flexible – provides for surface treatment or bioconjugation without steric hindrance
Therefore, an important approach - pegylation, by coupling a PEG structure to a compound, finds a great number of applications in pharmaceutical and biological fields. Pegylation technology is now widely used to modify active pharmaceutical ingredients, peptides, proteins, antibody components, oligonucleotides, and so forth, to lend some advantages as follows:
increased blood circulation of the drug
decreased frequency of administration
On a molecule of protein, peptide, or other components, there may exist multiple reactive sites being attachable with PEG moiety. This would raise the concerns about the efficacy and reproducibility of the pegylated product from lot to lot. To address this issue, we use some site-specific pegylation methods, through which the pegylated products can be made with the consistent efficacy. Furthermore, in the recent year, PEG2-based pegylation has been proven more effective than the first generation of pegylation approach for many applications. We are ready to collaborate with you in this field to boost the value of your promising products.