PEGylation

PEG, polyethylene glycol, traditionally refers to the one with low molecular weight (MW<20 kDa); while
its higher MW adduct is usually called as polyethylene oxide (PEO). PEG has several chemical
attributes that make it especially useful in various biological, pharmaceutical, and chemical settings. For
example:
  • Non-toxic / non-immunogenic – can be added to media and attached to surfaces and conjugated
    to molecules without interfering with cellular functions or target immunogenicities
  • Hydrophilic – attachment to proteins and other biomolecules decreases aggregation and
    increases solubility
  • Highly flexible – provides for surface treatment or bioconjugation without steric hindrance

Therefore, an important approach - pegylation, by coupling a PEG structure to a compound, finds a
great number of applications in pharmaceutical and biological fields. Pegylation technology is now
widely used to modify active pharmaceutical ingredients, peptides, proteins, antibody components,
oligonucleotides, and so forth, to lend some advantages as follows:
  • increased bioavailability
  • increased blood circulation of the drug
  • optimized pharmacokinetics
  • decreased immunogenicity
  • decreased frequency of administration

On a molecule of protein, peptide, or other components, there may exist multiple reactive sites being
attachable with PEG moiety. This would raise the concerns about the efficacy and reproducibility of the
pegylated product from lot to lot. To address this issue, we use some site-specific pegylation methods,
through which the pegylated products can be made with the consistent efficacy. Furthermore, in the
recent year, PEG2-based pegylation has been proven more effective than the first generation of
pegylation approach for many applications. We are ready to collaborate with you in this field to boost
the value of your promising products.

Please explore our
PEG derivative products, or contact us to see how we can meet your needs for PEG
or pegylation products via our custom synthesis service.
Polycaprolactones
Polylactide-co-glycolide
Polycaprolactone-co-lactides
Polycaprolactone-co-glycolide
Polymer Crosslinkers
Biodegradable Crosslinkers
Amphiphilic Polymers
Anionic Polymerization
Ring-Opening Polymerization
Free Radical Polymerization
Ethoxylation
Chemical synthesis, organic synthesis, intermediate synthesis, organic analysis, compositional analysis, deformulation
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