PEGylation

PEG, polyethylene glycol, traditionally refers to the one with low molecular weight (MW<20 kDa); while its higher MW
adduct is usually called as polyethylene oxide (PEO). PEG has several chemical attributes that make it especially useful
in various biological, pharmaceutical, and chemical settings. For example:
  • Non-toxic / non-immunogenic – can be added to media and attached to surfaces and conjugated to molecules
    without interfering with cellular functions or target immunogenicities
  • Hydrophilic – attachment to proteins and other biomolecules decreases aggregation and increases solubility
  • Highly flexible – provides for surface treatment or bioconjugation without steric hindrance

Therefore, an important approach - pegylation, by coupling a PEG structure to a compound, finds a great number of
applications in pharmaceutical and biological fields. Pegylation technology is now widely used to modify active
pharmaceutical ingredients, peptides, proteins, antibody components, oligonucleotides, and so forth, to lend some
advantages as follows:
  • increased bioavailability
  • increased blood circulation of the drug
  • optimized pharmacokinetics
  • decreased immunogenicity
  • decreased frequency of administration

On a molecule of protein, peptide, or other components, there may exist multiple reactive sites being attachable with
PEG moiety. This would raise the concerns about the efficacy and reproducibility of the pegylated product from lot to lot.
To address this issue, we use some site-specific pegylation methods, through which the pegylated products can be
made with the consistent efficacy. Furthermore, in the recent year, PEG2-based pegylation has been proven more
effective than the first generation of pegylation approach for many applications. We are ready to collaborate with you in
this field to boost the value of your promising products.

Please explore our
PEG derivative products, or contact us to see how we can meet your needs for PEG or pegylation
products via our custom synthesis service.
Polylactide-co-glycolide
Polycaprolactone-co-lactides
Polycaprolactone-co-glycolide
Polymer Crosslinkers
Biodegradable Crosslinkers
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